Author: Mokhtar

  • How many marbles do you have?

    How many marbles do you have?

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    Perhaps one of the most challenging aspects of motherhood with a chronic illness is helping your children understand what’s going on with your body and encouraging acceptance about how your illness affects them. How can you help them develop empathy for what you are experiencing, especially if your illness is invisible? Where is the line between being honest and worrying them? What’s the best way to address their concerns in child-friendly language? This is a topic that will probably need to be an ongoing conversation in your family – and sometimes reading a book together can help!

    Click below to read a review of “How Many Marbles Do You Have? Helping Children Understand the Limitations of People with Chronic Fatigue Syndrome and Fibromyalgia” by Melinda Malott.

    Children’s book review: How many marbles do you have?

    Moms facing forward

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  • September 2023 Schedule — Bone Talk

    September 2023 Schedule — Bone Talk

    shutterstock 2149320159

    Bone Buddies Virtual Support Group: September 2023 schedule

    Join the Bone Buddies Online Virtual Support Group this September! Weekly sessions cover topics ranging from diet, exercise, treatment and more!

    • Saturday, September 16 at 10am CT: Bone Buddies presentation on epigenetics and low bone density

    • Thursday, September 21 at 2:00 PM CT: Healthy Eating Session

    • Saturday, September 23: Practice session at 10am CT; Open Forum/Best Practices at 11am CT

    • Wednesday, September 27 at 5:30 PM CT: Review of September’s Bone Buddies presentation on epigenetics and low bone density

    • Saturday, September 30: Practice session at 10am CT; Review of the Bone Buddies presentation on epigenetics and low bone density at 11am CT

    If you would like to join one of the sessions, please email Elaine Henderson at eshenderson214@gmail.com for the Zoom links. Feel free to share the meeting information with others who may be interested in attending!

    About Bone Buddies

    The Bone Buddies virtual online support group is open to everyone and typically meets on the second Saturday of every month at 10 a.m. Central Time on Zoom. On weeks when there is no support group meeting, the group usually meets on Zoom on all other Saturdays at 10 a.m. Central Time for free practice sessions.

    A discussion about healthy eating also takes place every third Thursday at 2:00 PM Central Time on Zoom. You can submit questions to a registered dietitian. She will then receive an overview of the questions. She will also answer your questions if you attend the meeting.

    Group meetings are a fun, relaxing way to learn new information about bone health and managing osteoporosis. It can also be a great way to meet others dealing with low bone density.

    Send an email to Elaine Henderson at eshenderson214@gmail.com for the Zoom links. Feel free to share the meeting information with others who may be interested in attending!

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  • Peptides, bone health and prolonging your health with Nathalie Niddam + BoneCoach™ Osteoporosis and osteopenia – BoneCoach™

    Peptides, bone health and prolonging your health with Nathalie Niddam + BoneCoach™ Osteoporosis and osteopenia – BoneCoach™

    Have you come across the terms ‘peptides‘ And ‘bioregulators‘, but not sure what they mean for your health?

    Are you curious about how these miracles can support you in your… osteoporosis trip?

    What if there was a way? not just to add years to your life, but life to your years?

    Dive into this insightful episode for answers!

    Come with me as I sit down Nathalie Niddam, a podcast host, a lifelong biohacker, a holistic nutritionist, a human resource, and an epigenetic coach. Together we unravel the mysteries of peptides and bioregulators and shed light on them revolutionary potential for improving bone health and redefining what it means to age gracefully. Come with us the science, evidence, and real-world applications that might just be the game-changer you’ve been waiting for.

    Episode timeline

    0:00 – Episode begins

    1:20 – Introduction of guest Nathalie Niddam

    2:39 – Nathalie’s journey to health, longevity, biohacking and peptides

    7:01 – Understanding what peptides are

    11:27 – Exploring the nature of bioregulators

    16:05 – Beneficial peptides and bioregulators for the 50 to 70+ age group, with an emphasis on osteoporosis and bone health

    20:48 – Pineal and thymus bioregulators: improving quality of life and bone density

    23:02 – Discussion of evidence, human studies and recipe questions

    27:35 – Other important bioregulators to know about

    32:52 – Acquiring and administering peptides in the US and Canada

    40:23 – The role of peptides in bone healing and their relationship to growth hormones

    46:09 – Comparing stem cells and peptides

    48:46 – Key takeaways for the audience

    51:10 – Connecting with Nathalie Niddam

    Sources mentioned

    **Show notes @ https://bonecoach.com/natniddam-peptides-osteoporosis-superhuman-performance

    Below you will find Nathalie Niddam’s sources!

    >> Join her Facebook community – The Optimizing Superhuman Performance Group – HERE

    >> Click here to watch the Biohacking Superhuman Performance Podcast

    >> Connect with Nathalie on her website

    What can you do to support your bone health and this podcast?

    1. Press the “Subscribe” button on your respective podcast player (i.e. Apple, Google, Spotify, Stitcher, iHeart Radio and TuneIn). Never miss an episode that can help improve your bone health.

    2. Leave a review. The more positive ratings and reviews and the more subscribers we have, the more people can find us and get the answers to the questions they need. Thank you! 🙂

    3. Tell a friend about The Bone Coach Podcast or share via text, email or social. Do you know of a Facebook group where people can benefit from this information? Feel free to hit any of the share buttons below.

    About Nathalie Niddam:

    Nathalie Niddam is a podcast host, Longevity Biohacker, holistic nutritionist, human potential and epigenetic coach, and a self-proclaimed science nerd with a passion for human health.

    A few years ago she came across peptides at a health optimization conference. She was fascinated by the potential these small proteins seemed to offer. This became the catalyst for the launch of her large and growing Facebook community – the Optimizing Superhuman Performance Group – to fuel the growing interest in these incredible connections. A year later, she launched the Biohacking Superhuman Performance Podcast, which is now rated as a top 100 podcast in its category in the US and Canada.

    Nat’s passion is looking at longevity through the lens of everything we can do in every area of ​​our lives to promote vibrant health, boundless energy focused on a healthy mind and body! She works one-on-one with clients, manages two large and growing communities, and regularly speaks at international conferences on the regenerative powers of peptides and peptide bioregulators.

    Medical disclaimer

    The information shared above is for informational purposes only and is not intended as medical or nutritional therapy advice; it does not diagnose, treat or cure any disease or condition; it should not be used as a substitute or substitute for medical advice from physicians and trained medical professionals. If you are under the care of a healthcare professional or are currently taking prescription medications, you should discuss any changes in your diet and lifestyle or possible use of nutritional supplements with your doctor. You should not stop prescribed medications without first consulting your doctor.

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  • Which sports have the most ACL tears?

    Which sports have the most ACL tears?



    Document

    Image by South_agency from Getty Images Signature from Canva Pro

    The greatest risk of anterior cruciate ligament injuries or ACL injuries is for people who participate in sports that involve a lot of changing direction, twisting and jumping.1 Females are 2-8 times more likely to injure their ACL compared to males. Read this blog to learn more about the issue that makes women more likely to tear their ACL. Most ACL injuries occur between the ages of 15 and 45.1

    In which sports do most ACL injuries occur?

    Studies consistently report basketball and football as sports that cause ACL injuries.1,2 However, it is possible to injure the ACL in other sports that require a lot of twisting, cutting (changing direction quickly), jumping and contact sports.1 Female athletes are generally more at risk for ACL injuries.1

    Using data from the National Collegiate Athletics Association (NCAA) Injury Surveillance System (ISS), 5,000 ACL injuries were recorded between 1988 and 2004. Based on this data, sports are ranked below based on the number of ACL injuries. The left side of this table shows the number of ACL injuries that have occurred as a percentage compared to all other injuries in a sport. On the right side of this table the number of ACL injuries registered per 1000 matches and training (also called exposures).

    ACL injuries as a percentage compared to all injuries3 Injury rate per 1000 exposures3
    1. Women’s Basketball (tie) 1. Men’s Spring Football (tie)
    1. Women’s gymnastics (tie) 1. Women’s gymnastics (tie)
    2. Women’s Lacrosse 2. Women’s football
    3. Women’s football 3. Women’s basketball
    4. Men’s Spring Football 4. Men’s football
    5. Men’s football 5. Men’s football
    6. Women’s Softball 6. Men’s wrestling
    7. Women’s volleyball 7. Men’s wrestling
    8. Women’s hockey 8. Men’s football
    9. Men’s wrestling 9. Women’s volleyball
    10. Men’s Basketball 10. Women’s Softball
    11. Men’s football 11. Women’s hockey
    12. Men’s Ice Hockey 12. Men’s Basketball
    13. Women’s Ice Hockey 13. Men’s Ice Hockey
    14. Men’s Baseball 14. Women’s Ice Hockey

    If you have suffered an ACL tear from playing any of the above sports, there is an app, Curovate, to help you with your daily recovery. Curovate offers recovery exercises for ACL injuries and ACL surgery to help you return to the sport you love. Curovate provides your daily physiotherapy exercises, tracks your daily training progress, has in-app chat with a physiotherapist to answer your questions and allows you to measure your knee range of motion with the app. Download Curovate via the links below.

    If you need more tailored help during your ACL injury or ACL surgery, check out our Virtual Physiotherapy page to book your 1-on-1 video session with a physiotherapist.

    acl knee physical therapy 1080x1080 2
    Download it on Google Play

    Other blogs related to ACL injuries:

    References


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  • You Don’t Look Sick – Living With Rheumatoid Arthritis: DAY 2 IN YOSEMITE

    Got ready early this morning to go to Yosemite Valley. I got in my car and drove for miles along route 140 which brought me to the entrance to Yosemite National Park. I was supposed to meet my guide Paola at 9am for a half day of walking. We started our day by visiting a beautiful riverbed and sitting down and meditating. It was wonderfully close to the water and looked out on granite mountains with trees. After our meditation we went for a walk (isn’t it just walking?) and I saw a waterfall, Half Dome, Sentinel, and walked through a meadow. The only animals I saw were a family of ducks swimming in the water. I tested the water and it was very cold. The meadow we walked through had grass as high as my hips with goldenrod and milkweed. It was a very beautiful day. Paula was very patient and took me to many places to get the best photo.

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    After driving back to the hotel, I had an appointment for a bath. It was great for the first 15 minutes. Then I started getting a stabbing feeling in my lower back and my leg. I got out of the bath and the spots were red. Thinking I was being bitten by something, I came home and took a shower. Then I applied some antiseptic to the areas. Turns out it may have been a reaction to the eucalyptus in the tub. Three hours later and it’s gone.

    I met my meditation group online and did a healing meditation. Then I went to the restaurant for dinner. I’m so full.

    That was day 2. I contacted Lucky and she is starting to enjoy watching football on TV. Never too late to start a new hobby!

    See you tomorrow…

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  • Are you at risk of vulnerability?  New study offers hope for older adults

    Are you at risk of vulnerability? New study offers hope for older adults

    A meta-analysis published in 2021 provides compelling evidence that physical activity interventions positively impact the health and well-being of frail and pre-frail older adults.

    Frailty is a somewhat loosely defined condition, which complicates research into effective interventions. In general, it describes a state of increased fragility that can accompany aging.

    Today we delve into these complexities to better understand how we can prevent frailty and the associated negative health consequences of aging.

    Defining vulnerability and pre-vulnerability

    Frailty is a clinically diagnosable condition in which an older adult is at increased risk for poor health outcomes, including falls, hospitalization, and mortality. Although frailty is clinically recognized, there is no universally accepted measure for its diagnosis.

    In 2001, a group of researchers from the Center on Aging and Health at the John Hopkins Medical Institution proposed that to be considered frail, a patient must meet three of five diagnostic criteria: low grip strength, low energy, slowed walking speed, low physical condition. activity and/or unintentional weight loss.1

    Pre-frailty refers to a condition in which a person is at risk of developing frailty. An older adult who meets only one or two of the diagnostic criteria listed above may be considered pre-frail.

    A peer-reviewed scientific article published in the Cork Open Research Archive in 2021 provided a consensus statement from 23 experts on pre-frailty. These experts agreed that pre-frailty can be caused by physical, cognitive, nutritional, social and socio-economic factors.2

    They agreed that pre-frailty is both preventable and reversible, and emphasized the need for health professionals to monitor patients and recommend timely interventions.

    Short content

    Frailty is a condition in which older adults are at increased risk for poor health outcomes, including falls, hospitalizations, and mortality. Diagnostic criteria include low energy, slowed walking speed, low physical activity, and/or unintentional weight loss. Pre-frailty is a state in which one is at risk of developing frailty. Experts agree that pre-frailty is both preventable and reversible with timely interventions.

    How to prevent or reverse vulnerability

    A meta-analysis published in 2021 analyzed 26 studies involving 8,022 pre-frail and frail older adults. Each of the studies measured the impact of a physical activity intervention on participants’ health outcomes.3

    The reviewers included studies that measured different types of physical activities, including muscle strengthening, aerobics, mobilization and rehabilitation, and combinations of aerobic and strengthening exercises.

    The researchers noted that only a few studies used frailty as an outcome, and that the inconsistent application of these methods made the study results inconclusive. Despite that uncertainty, the study authors observed positive effects on participants’ health outcomes after physical activity interventions.

    The researchers included the following in the conclusion of their article:

    “Our study demonstrated a significant benefit of several types of physical activity interventions on selected outcomes, including mobility, ADLs, cognitive functioning, quality of life and frailty, compared to control groups in frail adults aged 65 years or older. Effect sizes ranged from small to large, with low to moderate certainty of evidence. When we looked at all physical activity interventions together, there was a large effect on frailty, a medium effect on quality of life, ADLs and mobility, and a small effect on cognitive functioning.”3

    The main conclusion is that interventions involving physical activity can positively influence several health outcomes, including frailty.

    Short content

    A meta-analysis of 26 studies found that physical activity had a positive impact on a variety of health outcomes among older frail and pre-frail research participants.

    Frailty, pre-fragility and bone health

    Frailty has a direct relationship with bone health. Outcomes of frailty, such as increased risk of falls, decreased physical function, and sarcopenia, threaten bone health. Sarcopenia is the loss of muscle mass. It harms the body’s ability to build new bone because bone adds mass in response to the tension exerted by the muscles.

    Pre-frailty may carry the same risks. Fortunately, prevention and reversal are possible, according to the 2021 consensus statement on pre-frailty. These experts stated:

    “Pre-frailty can be reversed or mitigated through targeted interventions, including physical activity, nutritional interventions, healthy lifestyle and social participation, tailored to the individual.”2

    These intervention strategies will sound familiar to Savers, as they form the pillars of the Osteoporosis Reversal Program. The overlap strengthens confidence in the Save Institute and illustrates the links between frailty, pre-frailty and bone health.

    It’s also great news for those already using the ORP to pursue healthier bones; The same interventions that the ORP uses to build strong bones will help prevent or reverse the components of frailty and pre-frailty.

    Short content

    The consequences of frailty threaten bone health, including the risk of falls, reduced physical function and muscle loss (sarcopenia). Pre-frailty is a predictor of the same risks, but experts agree it can be reversed and prevented through interventions such as physical activity, diet and lifestyle changes. These are the main strategies used by the Osteoporosis Reversal Program.

    What this means for you

    Regular physical activity is essential, both for preventing frailty and building strong and healthy bones.

    The Save Institute responded to the need for accessible, adaptable, and easy to maintain exercise programs by creating SaveTrainer. SaveTrainer is a digital platform for creating your ideal set of physical activities, guided by professional trainers and tailored to your exact needs and abilities.

    Whether you’re interested in yoga flows, strength training, guided meditations, aerobic workouts or a combination of these: SaveTrainer offers all this and more. Because it’s all online, it’s available to you anywhere, anytime, without restrictions.

    You have the power to adopt healthy activity habits that will keep your body, mind, and bones strong and long-lasting. Embrace your power and live your life to the fullest.

    References

    1 https://pubmed.ncbi.nlm.nih.gov/11253156/

    2 https://cora.ucc.ie/server/api/core/bitstreams/6dd8443a-1f49-4744-9727-04169dfd768b/content

    3 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8315283/



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  • Researchers suggest a new approach to testing treatments for osteoarthritis

    Researchers suggest a new approach to testing treatments for osteoarthritis

    Osteoarthritis (OA) is the most common form of arthritis and is one of the top 10 conditions that contribute to the number of years lived with a disability – a measure that reflects the impact a disease has on quality of life before it disappears or leads to death. To date, no treatments have been approved that slow the progression of the disease. The development of treatments has been frustrating in part because animal models of disease caused by joint trauma poorly reflect the human disease, which usually occurs over many years and without prior trauma.

    Researchers from Boston University Chobanian & Avedisian School of Medicine now propose to study individuals after they suffer knee trauma, such as anterior cruciate ligament (ACL) tears.

    “Given the repeated, expensive, and discouraging past failures in developing effective treatments for osteoarthritis, a new approach is needed that focuses research for effective treatments on people with early disease,” said corresponding author David T. Felson , MD, MPH, professor of medicine and epidemiology at the School of Medicine and Boston University School of Public Health.

    While most patients recover after sustaining a serious joint injury, such as an ACL tear, some experience persistent pain and develop osteoarthritis. Felson suggests that sufficient numbers of such patients exist and can be identified in advance to form a risk group in which treatments to prevent disease can be tested.

    Current treatment options that reduce joint pain, such as nonsteroidal anti-inflammatory drugs (NSAIDs), are successful in some patients, but their use is limited by their toxicity. Exercise or weight loss are effective, but long-term compliance is poor. The number of total knee replacement surgeries is rising rapidly, indicating that nonsurgical treatments have not successfully alleviated patients’ pain and disability.

    Researchers from BU and Cleveland Clinic reviewed data from the MOON (Multicenter Orthopedic Outcomes Network) cohort, a group of 2,340 individuals who underwent ACL reconstruction (ACLR) after traumatic tears. The MOON researchers reported that 26% of ACL reconstruction patients who responded had at least moderate knee pain with daily activities, especially climbing stairs and walking. They also found that 16.6% had a KOOS (Knee Injury and Osteoarthritis Outcome Score) pain score of less than 80 (scale 0-100 with 100 being no pain), indicating that mild to moderate pain is not rare after ACLR.

    By using the MOON risk factors – which include pain and structural changes in all joint tissues, especially cartilage loss – to select individuals at high risk for subsequent pain, they were able to create a cohort at high risk for substantial post-ACLR pain . “This approach offers the potential to prevent disease and is especially valuable in targeting young adults who, following a knee injury, may have significant joint pain and disability for years before they are considered for joint replacement,” he adds.

    These findings appear online in the Annals of the rheumatic diseases.

    Funding for this study was provided by the Arthritis Foundation and by the National Institutes of Health (NIH P30 AR072571).

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  • Turning the Page to Good Bone Health – Bone Talk

    Turning the Page to Good Bone Health – Bone Talk

    shutterstock 143247136 3

    October isn’t just the month of falling leaves and pumpkin-spiced lattes; it’s also National Book Month! Like a well-written novel, our bones have their own story, and it’s up to us to make sure it’s a story of strength and resilience.

    The prologue: family history

    Knowing whether there is a history of osteoporosis or fractures in your family can provide valuable insight your own risk factors. Genetics plays an important role, and a family history of these conditions can increase your susceptibility. By recognizing this family bond, you can take proactive steps to protect your bone health through lifestyle choices, regular checkups and early screenings. This knowledge will allow you to create a healthier story for yourself and potentially break the cycle of bone health problems, ensuring a stronger, more resilient future.

    Chapter 1: Building a solid foundation

    Every great book starts with a strong opening chapter, and your journey to bone health is no different. You need to lay the foundation for strong bones early in life. Childhood is the crucial period for bone building that is the cornerstone for lifelong skeletal health. This phase is crucial because our body builds up bone mass more quickly peak bone mass usually reached in the late teens or early twenties. It’s the time when the choices we make in diet, physical activity and overall lifestyle have a significant impact on our skeletal strength for years to come. Neglecting this critical period can lead to weaker bones, making people more susceptible to fractures and conditions such as osteoporosis as they get older. That’s why focusing on bone health during childhood is a long-term investment in a healthier and more active future.

    Chapter 2: The main characters

    In the literary world, characters drive the plot forward, and in the world of bone health calcium and vitamin D play leading roles. These essential nutrients help your bones stay strong and resilient. Just like finding the perfect cast for a movie adaptation, be sure to include dairy products, leafy greens, and fortified foods in your diet to get your daily dose of calcium and soak up the sun for vitamin D. Other nutrients such as vitamin C, vitamin K, potassium and magnesium also play an important role.

    Chapter 3: The Plot Twist

    Osteoporosis is a bone-weakening condition that can sneak up on you like an unexpected twist in a mystery novel. The disease causes a gradual weakening of bone density and quality, making them more vulnerable. Over time, this imbalance can lead to porous, brittle bones, increasing the risk of fractures, especially in the hip, spine and wrist. Osteoporosis often progresses without symptoms until a rupture occurs, earning it the nickname “the silent disease.” Talk to your healthcare provider about when to get a bone density test, especially if you’re at risk.

    Chapter 4: Making choices

    In literature, characters often face challenges and have to make life-changing decisions. Likewise, in the quest for good bone health, you have the power to make positive choices. Regular physical activity, including weight-bearing exercises and strength training, can help keep your bones strong and resilient. Also consider your lifestyle choices: avoid excessive caffeine and soft drink consumption, and don’t forget the importance of: good night.

    Chapter 5: Aging gracefully

    As we reach the final chapter of our bone health story, it’s essential to remember that aging is a natural part of life, like the closing words of a beloved book. With proper care and attention, you can age gracefully and maintain good bone health. Please note how menopause and hormonal changes can affect your bone density. Continue to eat well, stay active, and consult your doctor for advice on supplements or medications if necessary.

    Epilogue: The joy of reading

    Just as a well-written book can transport you to different worlds, a healthy body can take you on countless adventures. In the words of Louisa May Alcott, “She loves books too much, and it has changed her brain.” Well, you can never love good bone health more! And if you like books on cassette or podcasts, consider it to coordinate to develop health-related content that you can learn while reading or listening. As we celebrate National Book Month, remember that your bone health story is one you can influence, shape and improve. Let your journey be a page turner full of strength, resilience and a happy ending. After all, the story of your bones is a story worth telling and living to the fullest.

    Recommended reading list

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  • Find out how your ACL recovery is going

    Find out how your ACL recovery is going

    For example, twelve weeks later one of our clients, a 39-year-old CrossFit athlete named Josh, scored a 75/80 on the LEFS. Comparing this result to the graph, he is almost 20% ahead of the average ACL recovery.

    His PT was extremely impressed with his progress and offered the following thoughts:

    By combining my physical therapy care with Accelerate ACL protocols at home, my patient experienced an increase in range of motion, increase in strength, and an overall decrease in pain. Three months postoperatively, his daily functional activity scores were 94%. He has set a new standard for our ACL recovery.”

    Remember, this is just one example. Other athletes may find that they fall a little below the curve. That’s okay – keep working at it and you’ll get there. Ultimately, we hope you can use this information to start a conversation with your doctor, PT, or trainer about where you are in the ACL recovery process. As is the case with most things in life, try not to be ‘too high’ or ‘too low’ about what the score is telling you.

    No matter what happens, your goal for tomorrow is the same. Be consistent, stay disciplined in your approach and work hard.



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  • CORRECTION: The Board of Directors of Bioretec Ltd has decided on a new option program 2023-1

    CORRECTION: The Board of Directors of Bioretec Ltd has decided on a new option program 2023-1

    TAMPERE, Finland, October 20, 2023 /PRNewswire/ — “CORRECTION: Bioretec Ltd is correcting the company announcement published today, October 20, 2023, at 1:00 PM. There was an error in the English version of the release. According to the English version of the press release, the subscription price for a share subscribed with one option right was EUR 2.48. The correct subscription price is 2.84 euros per share. This corrected subscription price has been updated to the announcement below and the attached option plan document 2023-1.

    The Board of Directors of Bioretec Ltd decided on October 20, 2023, based on the authorization received from the annual general meeting of the company on May 26, 2023, to introduce a new option program as an incentive scheme for the employees, consultants and members of Bioretec Ltd. the Key Opinion Leader group of the company and its subsidiaries. There is a compelling financial reason for issuing option rights, as the option program is part of the incentive and commitment program of the employees, consultants and members of the Key Opinion Leader group of the company and its subsidiaries.

    A total of up to 1,000,000 option rights will be issued, entitling their owners to subscribe to a total of up to 1,000,000 new shares of the company. The option rights are issued free of charge. Based on the option rights, shares can be subscribed as follows:

    • 25% of the option rights granted to the holder of the option right: The subscription period for shares starts on the first anniversary of the decision of the Board of Directors to grant the option rights to the holder of the option right;
    • the remaining 75% of the option rights given to the option right holder: The share subscription period begins monthly in installments of 1/36th per month on the last day of each month, such that the share subscription period for the first 1/3 The 36th installment commences on the last day of the month following the first anniversary of the decision of the Board of Directors to grant the option rights to the holder of the option right.

    The subscription period for the shares ends on December 31, 2029.

    After any subscriptions to shares, the shares subscribed for with option rights to be issued will amount to a maximum of approximately 4.9% of all shares and votes of the company. As a result of the subscriptions for shares with option rights, the number of shares in the company can increase by a total of up to 1,000,000 shares.

    The subscription price for a share subscribed with one option right is EUR 2.84, which is the trading volume weighted average quotation of the share on Nasdaq Helsinki Ltd, maintained Nasdaq First North Growth Market Finland marketplace from July 19, 2023 to 19 October 2023, increased by 10%.

    The subscription price for the shares will be added to the company’s reserve for invested unrestricted equity. The amount of dividends and distribution of assets per share paid will be deducted from the subscription price of the shares.

    The theoretical market value of one option right is approximately €1,283 and the theoretical market value of all option rights together is approximately €1,283,357. The theoretical market value of an option right has been calculated using the Black & Scholes valuation model for stock options with the following input factors: valuation date October 19, 2023, share price EUR 2.45, share subscription price EUR 2.84, risk-free interest rate 3.46%, term of option rights 6.21 years and volatility 55.17%.

    The target group of the stock option plan includes approximately 35 people. The terms and conditions of the option program are attached to this announcement.

    Other questions

    Timo Lehtonen, CEO, +358 50 433 8493
    Johanna Salko, CFO, +358 40 754 8172

    Certified advisor

    Nordic certified advisor AB, +46 70 551 67 29

    Information about Bioretec

    Bioretec is a global Finnish medical device company that continues to pioneer the use of biodegradable orthopedic implants. The company has built up unique competencies at the biological interface of active implants to improve bone growth and accelerate fracture healing after orthopedic surgery. The products developed and manufactured by Bioretec are used in approximately 40 countries worldwide.

    Bioretec is developing the new RemeOs™ product line based on magnesium alloy and hybrid composite, introducing a new generation of strong biodegradable materials for improved surgical results. The RemeOs™ implants are absorbed and replaced by bone, eliminating the need for removal surgery and facilitating fracture healing. The combination has the potential to eliminate the need for titanium implants and help clinics achieve their Value-Based Healthcare goals while focusing on value for patients through efficient healthcare delivery. The first market authorization for the RemeOs™ product was received in the US in March 2023, and in Europe the CE mark is expected to be received in the first quarter of 2024. Bioretec is positioning itself to enter the over $7 billion addressable global orthopedic trauma space. market and become a game changer in the surgical treatment of bone fractures.

    Better Healing – Better Living. www.bioretec.com

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