download 2026 03 22T112538.395
|

Fibroblast multiplicity in RA: a synovial state of the art

 

  • Zhang, F. et al. Defining inflammatory cell states in rheumatoid arthritis synovial tissues by integrating single-cell transcriptomics and mass cytometry. Wet. Immunol. 20928–942 (2019).

    Article PubMed PubMed Central Google Scholar

  • Smith, MH et al. Drivers of heterogeneity in synovial fibroblasts in rheumatoid arthritis. Wet. Immunol. https://doi.org/10.1038/s41590-023-01527-9 (2023).

    Article PubMed PubMed Central Google Scholar

  • Nygaard, G. & Firestein, G.S. Restoring synovial homeostasis in rheumatoid arthritis by targeting fibroblast-like synoviocytes. Wet. Rev. Rheumatoid. 16316–333 (2020).

    Article PubMed PubMed Central Google Scholar

  • Müller-Ladner, U. et al. Synovial fibroblasts from patients with rheumatoid arthritis adhere to and invade normal human cartilage when grafted into SCID mice. Ben. J. Pathol. 1491607–1615 (1996).

    PubMed PubMed Central Google Scholar

  • Ainsworth, RI et al. Systems biology analysis of fibroblast-like synoviocytes in rheumatoid arthritis implicates cell lineage-specific transcription factor function. Wet. Just. 136221 (2022).

    Article CAS PubMed PubMed Central Google Scholar

  • Yan, M. et al. ETS1 regulates pathological tissue remodeling programs in disease-associated fibroblasts. Wet. Immunol. 231330–1341 (2022).

    Article CAS PubMed Google Scholar

  • Wei, K. et al. Notch signaling drives synovial fibroblast identity and arthritis pathology. Nature 582259–264 (2020).

    Article CAS PubMed PubMed Central Google Scholar

  • Boyle, DL et al. Enhancement of transcriptome fidelity after synovial tissue disaggregation. Front side. Of. 9919748 (2022).

    Article Google Scholar

  • Firestein, GS Invasive fibroblast-like synoviocytes in rheumatoid arthritis. Passive responders or transformed aggressors? Arthritis Rheumatism. 391781–1790 (1996).

    Article CAS PubMed Google Scholar

Source link

Similar Posts

  • |

    Driving after knee surgery

    What’s the one thing nearly 1.5 million Americans who had a procedure in 2022 desperately want to know? For most, it’s about reclaiming their independence and getting back to their normal routine. We recognize that a total joint replacement is a major event. It significantly impacts your daily mobility and overall sense of freedom. It’s completely natural to look forward to resuming all your regular activities once the operation is complete. driving after knee surgery Our goal is to equip you with clear, reliable information to navigate your healing journey safely. Understanding your personal recovery timeline is not just about convenience—it’s crucial for ensuring the safety of everyone on the road. We will explore the critical physical and mental factors that determine true readiness. This knowledge helps you make informed decisions alongside your medical team. Key Takeaways Regaining the ability to operate a vehicle is a common and important milestone after a major orthopedic procedure. Safety for yourself and others is the paramount concern when considering a return to this activity. Your specific recovery timeline is unique and depends on multiple factors, including which leg was operated on. Medication use, muscle strength, and pain levels are all critical indicators of your readiness. Consulting with your surgeon for a personalized assessment is an essential step before you resume. Being patient with your body during the healing process leads to better long-term outcomes. Planning for assistance with transportation in the initial weeks post-procedure is highly recommended. Understanding Knee Replacement and Recovery Robotically assisted surgery is revolutionizing how patients recover from joint procedures. Specialists like Dr. Jacob in Oklahoma City utilize these minimally invasive, rapid recovery techniques. Their goal is to help individuals return to their daily activities with less discomfort. What Is a Knee Replacement? A total knee replacement, or arthroplasty, is a highly successful procedure. It involves removing damaged tissue and bone from the joint. Surgeons then replace them with durable artificial components. This replacement surgery is typically performed when arthritis or injury severely limits natural mobility. The artificial joint restores smooth movement and alleviates pain. For many, it’s a life-changing operation. knee replacement surgery Overview of the Recovery Process The rehabilitation phase after a knee replacement requires patience. Patients often experience temporary weakness and a limited range of motion initially. This is a normal part of healing from the invasive surgery. Most people find this replacement surgery significantly improves their function. It allows them to eventually return to the activities they enjoy. We emphasize that a personalized recovery plan is key. Recovery Phase Primary Focus Typical Timeline Early (Weeks 1-2) Pain management, basic mobility, wound healing 1-2 weeks post-op Middle (Weeks 3-6) Building strength, improving range of motion 3-6 weeks post-op Late (Months 2-6+) Returning to normal activities, endurance building 2 months and beyond Understanding these phases helps set realistic expectations. Modern techniques aim to accelerate this recovery timeline. Working closely with your care team ensures the best outcome from your knee replacement surgery. Driving after knee surgery: Key Considerations Resuming control behind the wheel is a major milestone that hinges on two critical factors: medication management and physical rehabilitation. Your personal safety and the safety of others depend on an honest evaluation of both. pain medication and physical therapy for driving readiness We cannot overstate the importance of this dual assessment. It forms the foundation for a confident and secure return to operating a vehicle. Impact of Pain Medication on Driving Narcotic pain medication is a standard part of post-operative care. However, these drugs significantly dull mental alertness and slow reaction times. It is both illegal and dangerous to get behind the wheel while under their influence. Your ability to focus on complex traffic situations is compromised. You must be completely off such pain medication before considering any trip. Even lingering pain can be a dangerous distraction if it’s severe….

  • Brain biometrics helps identify sports concussions

    New brain biometrics could help determine whether an athlete is ready to return to play after a concussion, according to new research from the University of South Australia. Conducted in collaboration with the University of California San Francisco (UCFC), researchers found that changes in brain micro-movements – called ‘head pulses’ – could detect the lasting…

  • |

    Corin Group Achieves 510(k) Clearance for Apollo™ Platform: Revolutionary Robot-Assisted Total Knee Arthroplasty

    CIRENCESTER, UNITED KINGDOM, November 1, 2023 / EINPresswire.com / — Corin Group, an innovator in orthopedic procedures, is proud to announce 510(k) clearance for its Apollo™ Robotic-Assisted Surgical platform and ApolloKnee™ software application. This marks a major industry milestone in Corin’s continued commitment to helping surgeons increase satisfaction and successful outcomes for their patients when…

  • Your meniscus is probably not affected by your ACL reconstruction

      Meniscus procedures do not increase with delayed ACL reconstruction and rehabilitation: results from a randomized controlled trial. van der Graaff SJA, Reijman M, van Es EM, Bierma-Zeinstra SMA, Verhaar JAN, Meuffels DE. The British Journal of Sports Medicine, 2023; 57:78-82. Full text freely available Take home message People who initially receive rehabilitation with optional…

Leave a Reply

Your email address will not be published. Required fields are marked *