Author: Mokhtar

  • Global Scoliosis Management Market Report 2023: Market to Grow by $1 Billion by 2030 – Spinal Fusion Surgery Offers Major Opportunities

    Global Scoliosis Management Market Report 2023: Market to Grow by $1 Billion by 2030 – Spinal Fusion Surgery Offers Major Opportunities

    Dublin, October 26, 2023 (GLOBE NEWSWIRE) – The report “Scoliosis Management – ​​​​Global Strategic Business Report” has been added to ResearchAndMarkets.com’s to offer.

    The global scoliosis treatment market will reach $3.8 billion by 2030

    The global scoliosis treatment market, estimated at USD 2.8 billion in the year 2022, is expected to reach a revised size of USD 3.8 billion by 2030, with a CAGR of 4.1% over the analysis period 2022-2030.

    This data includes an analysis of the Thoracolumbosacral Orthosis (TLSO) and related orthosis markets worldwide. It includes current, historical, and future annual sales figures in thousands of dollars for the years 2022 through 2030, along with percentage compound annual growth rates (%CAGR).

    The analysis is segmented into different product types, including TLSO, Cervical Thoracic Lumbar Sacral Orthosis (CTLSO), Lumbosacral Orthosis (LSO), and Other Product Types. Furthermore, within these product types a distinction is made between the Pediatric and Adult segments.

    Thoracolumbosacral orthosis (TLSO), one of the segments analyzed in the report, is expected to register a CAGR of 4.4% and reach $2.9 billion by the end of the analysis period. Growth in the Cervical Thoracic Lumbar Sacral Orthosis (CTLSO) segment is estimated at 3.7% CAGR over the next eight years.

    The US market is estimated at $987.6 million, while China is expected to grow at a CAGR of 5%

    The US scoliosis treatment market is estimated to reach USD 987.6 million by the year 2022. China, the second largest economy in the world, is expected to reach a projected market size of USD 422.1 million by 2030, at a CAGR of 5% over recent years. analysis period 2022 to 2030.

    The data provides a 16-year perspective, breaking down the percentage of value sales for different geographic regions, including the US, Canada, Japan, China, Europe, Asia Pacific and the rest of the world, for the years 2014, 2023 and 2030 Finally, it provides a comprehensive analysis of the scoliosis treatment market, including annual sales figures from 2014 through 2030, and segmented analyzes for different geographic regions.

    Other notable geographic markets include Japan and Canada, each expected to grow by 3.1% and 3.4%, respectively, over the 2022-2030 period. Within Europe, Germany is expected to grow at a CAGR of approximately 4.1%.

    This comprehensive report also provides detail on the approaches that leading market competitors such as Aspen Medical Products, Bauerfeind AG and Boston Orthotics & Prosthetics are taking, providing invaluable insights that you as an executive can leverage.

    What’s new?

    • Special discussions on the global economic environment and market sentiment
    • Coverage on global competitiveness and key market shares of competitors
    • Multi-region market presence analysis – Strong/active/niche/trivial
    • Online interactive peer-to-peer collaborative custom updates
    • Access to digital archives and a trademarked research platform
    • Free updates for a year
    • Access curated YouTube video transcripts of market sentiments shared by CEOs, domain experts and market influencers through interviews, podcasts, press statements and event keynotes

    MARKET OVERVIEW

    • Scoliosis: An abnormal lateral curvature of the spine
    • Scoliosis Management/Treatment Options
    • COVID-19 is casting a shadow on the scoliosis treatment market
    • Competition
    • Scoliosis Management – ​​Percentage Market Share of Key Competitors Globally in 2023 (E)
    • Competitive Market Presence – Strong/Active/Niche/Trivial for Global Players in 2023 (E)
    • Great startup ecosystem
    • Global market analysis and prospects
    • The global scoliosis management market will demonstrate steady growth driven by innovations and advancements
    • North America holds a leading position in the global scoliosis management market
    • ThoracoLumboSacral Orthosis (TLSO) dominates the market
    • AIS remains the primary disease type segment
    • Pediatric/adolescent as an important age group segment
    • Hospitals and ASCs claim leading share
    • Technological advancements as pulsating trends drive the scoliosis treatment market forward
    • Increase R&D activity to drive market expansion
    • Market restrictions
    • Market challenges
    • Recent market activity
    • GLOBAL BRANDS

    MARKET TRENDS & DRIVERS

    • Rising prevalence of idiopathic and congenital scoliosis drives market growth
    • Spinal fusion surgery offers great opportunities
    • The demand for fusionless scoliosis surgery is increasing
    • Tying the vertebral body provides traction
    • Schroth therapy – a useful approach to treat scoliosis
    • Strong focus on minimally invasive spine surgery and increasing use of navigation and robotics in scoliosis surgery to increase prospects
    • Increasing cases of scoliosis in adults and a growing aging population to propel the adult segment
    • Increase healthcare spending to stimulate growth
    • Recent technological advances/innovations in the scoliosis treatment market
    • New Satellite Rod-Based Sequential Correction for Severe Rigid Spinal Deformities to Reduce Surgical Risks and Other Complications
    • ApiFix system for correcting moderate scoliosis with single curves
    • Shriners Hospitals for Children’s The Tether, a device for treating scoliosis, receives FDA approval
    • Minimally invasive spine surgeries are becoming commonplace, but long-term research into results is essential for wider adoption
    • Disruptive technologies in the spine space – a review
    • 3D printed braces have potential to improve the treatment of scoliosis

    FOCUS ON SELECTED PLAYERS(Total 91 recommended)

    • Aspen Medical Products, LLC
    • Bauerfeind AG
    • Boston Orthoses and prosthetics
    • Chaneco
    • Enovis
    • Fitted, Inc.
    • Horton’s Orthotics and Prosthetics
    • Lawall Prosthetics and Orthotics
    • Optec USA, Inc.
    • Orthotec
    • Ottobock SE & Co. KGaA
    • Spinal Technology Inc.
    • Real

    For more information about this report, visit https://www.researchandmarkets.com/r/ozemky

    About ResearchAndMarkets.com
    ResearchAndMarkets.com is the world’s leading source for international market research reports and market data. We provide you with the latest data on international and regional markets, key industries, top companies, new products and the latest trends.

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  • Effects of trunk training using motor imagery on the control ability and balance function of the trunk in stroke patients |  BMC Sports sciences, medicine and rehabilitation

    Effects of trunk training using motor imagery on the control ability and balance function of the trunk in stroke patients | BMC Sports sciences, medicine and rehabilitation

    General information

    Post-stroke patients with motor dysfunction who were hospitalized in the Department of Rehabilitation Medicine of our hospital from January 1, 2020 to January 1, 2022, aged 50 to 70 years old, were selected.

    Inclusion criteria: [12] The patient met the diagnostic criteria for stroke established at the Fourth National Academic Conference on Cerebrovascular Diseases in 1995, [13, 14] and stroke was diagnosed as the primary disease on CT or MRI. The time between disease onset and enrollment ranged from two weeks to three months. The patient’s vital signs were stable and the patient was conscious, able to understand the instructions and cooperate with the rehabilitation training. The patient’s score on the Kinesthetic and Visual Imagery Questionnaire (KVIQ) was ≥ 25 points. The patient signed the required informed consent form. Age between 50 and 70 years.

    Exclusion criteria: [14] The patient suffered from severe cardiac, hepatic or renal insufficiency, a malignant tumor, etc. The patient suffered from impaired consciousness, aphasia, mental disorder or severe cognitive impairment. The patient has had other craniocerebral diseases or traumatic sequelae in the past. The patient has previous severe osteoarticular disorders causing abnormal trunk function.

    Finally, a total of 100 patients with stroke and motor dysfunction were included, and they were divided into a control group and a trial group according to the random number table, with 50 cases in each group. There was no significant difference (P > 0.05) in general data such as gender, age, disease course and KVIQ between the two groups, and they were comparable. See Table 1 for details. This study was approved by the local ethics committee (approval number: 2018-ethical review-189) and conducted in accordance with the Declaration of Helsinki. All participants provided written informed consent.

    Table 1 Comparison of general data of patients such as gender, age, disease course and lesion site between the two groups

    Treatment methods

    The patients in the control group underwent routine rehabilitation therapy and remained in the supine position in the same environment for the same amount of time as the combined trunk motor imagery therapy. Meanwhile, the trial group received both routine rehabilitation therapy and combined trunk motor imagery therapy.

    Routine rehabilitation therapy

    The training included proper limb positioning, neuromuscular promotion techniques, such as the proprioceptive neuromuscular facilitation technique (PNF), Rood’s approach, motor relearning, occupational therapy, daily living training and traditional therapy. The participants received routine rehabilitation therapy for five hours a day, five times a week, for a period of four weeks.

    Motor image therapy

    The motor imagery therapy training consisted of six steps: [4, 14] Illustration of the task: The therapist first demonstrated and explained the content of the imagery training, asking the patients to carefully observe and identify which part of the limb was ‘active’, what kind of movement was to be performed, and the normal movement to master. feeling. Preview: Patients were asked to re-imagine the relevant movements. Motor imagery: Patients listened to the motor imagery instruction tape and practiced the imagery. Rehabilitation training: the patients repeatedly practiced the movements of imagery training. Problem solving: The patients learned relevant skills through repeated practice. Practical application: the patients convert relevant skills into practical skills. Before the motor images, a video of a normal person’s trunk movements was shown, including stable trunk movements with a Bobath ball, and balance movements while sitting, standing, and reaching to move a water cup. The 10-minute video and audio were shown to patients via a computer in a quiet treatment room. During each training session, patients were instructed to close their eyes and sit on a comfortable chair with their bodies relaxed. The patients then imagined the movement of their body based on the specific motor imagery instructions in the video. During the treatment, the therapist occasionally interrupted the patients to ask questions, to see if they could concentrate on the images of the physical movement. At the end of the session, the patients were asked to refocus their attention on their surroundings, after which they were sent back to their room and asked to feel their physical being. The patients were then asked to pay attention to the environmental sounds. Finally, the narrator counted down from 10 to 1, and the patients were asked to open their eyes when the countdown reached 1. A motor imagery video was shown only during the first treatment, after which the patients underwent motor imagery training according to the motor imagery. guidelines for imagery. The motor imagery therapy sessions were conducted for 30 minutes each, with a frequency of five times per week, for a total of four weeks.

    Observation indicators and evaluation methods

    The evaluation of the patient’s trunk control was performed before treatment and four weeks after treatment using Sheikh trunk control evaluation. The simple Fugl-Meyer assessment (FMA), the Berg rating scale (BBS), and the balance feedback trainer were used to evaluate the motor and balance functions of the patients. In addition, before and after treatment, the sEMG signals of the bilateral erector spinae and rectus abdominis in the maximum flexion and extension range at a uniform speed under the sitting position were measured by sEMG signals. All evaluations were performed in a blinded manner by the same evaluator.

    Sheik Hull Check Evaluation

    Sheikh is a scale for evaluating the ability to control the trunk. It involves four movements: turning from the supine position to the hemiplegic side, turning to the healthy side, sitting upright from the supine position and maintaining balance in a sitting position on the bed. The scoring method is: 0 points for non-completion, 12 points for completion but needing some assistance (grasping or leaning on an object), and 25 points for normal completion. A higher total score indicates better trunk control.

    BBS rating

    The balance function is divided into 14 items, from easy to difficult, and each item is scored based on a five-point scale: 0, 1, 2, 3, and 4. The highest score is 4 points and the lowest score is 0 points. . The highest integral score is 56 points, the lowest is 0 points. The higher the score, the better the balance function.

    Evaluation of motor functions

    FMA is used to evaluate motor function in patients. The highest score is 100. The higher the score, the better the patients’ motor functioning will be.

    Evaluation of balance feedback training equipment

    The ProKin 254P (PK-254P) balance feedback training device, manufactured by TecnoBody Ltd., Italy, was used to test the postural stability of the patients. Stability tests were performed in standing position with eyes open using the static mode of the PK-254P balancer. The standard standing posture includes: Bilaterally symmetrical standing with A1A5 as central axis. The patients raise their heads and look straight ahead. Both upper limbs are naturally placed on either side of the body. The medial edges of both feet are 10 cm apart and the highest point of the bilateral arches is on axis A3A5. Observation parameters are as follows: movement length, movement area, mean front-back movement speed, and mean left-right movement speed.

    sEMG signal acquisition

    While the patients are seated on a square stool, their trunk is subjected to anterior flexion and posterior extension in the maximum range at uniform velocity. The Shanghai NCC 8-channel sEMG signal acquisition system was used to acquire the bilateral erector spinae and rectus abdominis myoelectric signals. The electrodes were taped to the 3 cm lateral opening on the left and right sides of the L3 spinous process (erector spinae) and the 3 cm lateral opening on the left and right sides 3 cm above the navel (rectus abdominis). The conductive diameter of the electrodes was 1 cm and the distance between the electrodes was 2 cm. Dandruff and oil were removed with a fine gauze and alcohol before testing. The root mean square (RMS) of myoelectric signals was then analyzed. The test was repeated three times with an interval of 30 seconds to obtain the average value. The RMS of the bilateral rectus abdominis and erector spinae of the two groups was evaluated before treatment and four weeks after treatment.

    static analysis

    SPSS software version 16.0 was used to analyze the data. The measurement data is expressed as (\(\bar x \pm s\)). Parametric statistics were applied when the data collected met the assumptions of homogeneity of variance and normal distribution. When these assumptions were not met, non-parametric statistics were used. The paired sample T-test was used for pre- and post-treatment comparison within the same group, while the independent sample T-test was used for between-group comparison, and P< 0.05 indicated that the difference was statistically significant.

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  • Coconut protein pancake |  G.F

    Coconut protein pancake | G.F

    Looking for a healthy twist on a breakfast classic?

    Here it is!

    Our coconut protein pancakes recipe is sure to become a new favorite.

    Thanks to the coconut flour base and the addition of collagen, these pancakes are packed with protein and bone-healthy nutrients like potassium, iron, selenium and manganese.

    Because this recipe is ready in just ten minutes, you can make this pancake as an energetic start to the day; you can serve it during brunch; or enjoy it as a delicious, bone-boosting dessert.

    Make it this week!

    Bone Coach Recipes |  Coconut protein pancake |  Bone loss Bone Healthy diet Nutrients Osteoporosis

    Coconut protein pancake | GF | BoneCoach™ Recipes

    SERVES: 1

    TOTAL TIME: 10 minutes

    Ingredients

    1/4 cup (60 ml) coconut flour

    1 teaspoon (5 ml) baking powder (use grain-free arrowroot powder for paleo)

    1 scoop (10 g) collagen peptides (optional for more protein! Add an extra tablespoon of milk)

    2 large pasture eggs

    1 tablespoon (15 ml) avocado oil

    2 tablespoons (30 ml) milk of choice (non-dairy milk for paleo)

    1 tablespoon (15 ml) maple syrup (or liquid maple sweetener for keto)

    Directions

    1) Sift the coconut flour, baking powder and collagen (if using) into a mixing bowl. Add the remaining ingredients and beat everything together until smooth and combined.

    2) Heat a frying pan or griddle over medium heat. Once hot, lightly grease the skillet with avocado oil or ghee. Pour the pancake mixture into the frying pan and smooth the batter with a spatula or spoon, as it is quite thick. Cook for 4-5 minutes on each side, or until golden brown.

    3) Serve immediately with your favorite nut or seed butter and fruit.

    Recipe created by BoneCoach™ Team Dietitian Amanda Natividad-Li, RD & Chef.

    Medical disclaimer

    The information shared above is for informational purposes only and is not intended as medical or nutritional therapy advice; it does not diagnose, treat or cure any disease or condition; it should not be used as a substitute or substitute for medical advice from physicians and trained medical professionals. If you are under the care of a healthcare professional or are currently taking prescription medications, you should discuss any changes in your diet and lifestyle or possible use of nutritional supplements with your doctor. You should not stop prescribed medications without first consulting your doctor.

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  • Study uses motion capture to determine the best free throw shooters

    Study uses motion capture to determine the best free throw shooters

    Every basketball coach has told his players that free throws win games. A new study from the University of Kansas used innovative, markerless motion capture technology to determine the mechanics of skilled free throw shooters and better understand one of the biggest keys to success in the game.

    According to the study, skilled free throw shooters – who could make more than 70% of their shots – performed the shooting motion in a more controlled manner. They had lower knee and center of mass peaks and average angular velocities compared to non-experienced shooters. Also, skilled shooters achieved a greater release height and had less forward torso lean at the point of ball release.

    “These findings imply that the movement of basketball shooting is not as simple as some may think. Shooting efficiency cannot simply be attributed to one biomechanical variable. It is based on a mix of multiple segmental body movements performed in a controlled manner,” says Dimitrije. Cabarkapa, lead author of the study and deputy director of the Jayhawk Athletic Performance Laboratory.

    The study examined 34 men with at least four years of basketball experience, ranging from recreational to collegiate competitive levels. Each participant attempted 10 free throws with a 10-15 second rest interval between each attempt. A three-dimensional markerless motion capture system developed by the Southwest Research Institute (SwRI Enable, San Antonio, Texas), consisting of nine high-definition cameras (120 fps), was used to capture the biomechanical characteristics of free throw shooting movements and to analyse. .

    “We are very interested in analyzing basketball shooting mechanics and what performance parameters distinguish skilled and non-skilled shooters,” Cabarkapa said. “High-speed video analysis is one way we can do that, but innovative technological tools like markerless motion capture systems can allow us to dig even deeper into that. In my opinion, the future of sports science is based on the use of non-invasive and time-efficient testing methods.”

    The study, conducted at the Jayhawk Athletic Performance Laboratory, also found that when differentiating between made and missed shots by skilled free throw shooters, an overemphasis on release height could be counterproductive.

    “These findings can be metaphorically represented by some healthy habits of daily life. Exercise, drinking water and consuming enough vitamins and minerals are all very beneficial to our health. However, overdoing these things can be harmful in certain cases and can even production of the disease. the opposite effect than expected,” Cabarkapa said.

    The study, published in the journal Limits in sports and active life, was co-authored with Damjana Cabarkapa and Andrew Fry of the Jayhawk Performance Athletic Laboratory at KU; Jonathan Miller of KU’s Higuchi Biosciences Center; and Tylan Templin, Lance Frazer and Daniel Nicolella of the Southwest Research Institute.

    Using motion capture technology without markers is useful for several reasons, the authors said, because other motion capture systems that use markers to be placed on the skin or clothing have several problems, such as not staying in place and the participant’s awareness of the markers. which can change normal movement patterns. This is crucial when testing in a sport-specific environment, where efficiency is key. The use of markerless motion capture technology enables non-invasive assessment.

    Dimitrije Cabarkapa said that, to the authors’ knowledge, this is the first study to use this motion capture system to investigate the biomechanical characteristics of skilled free throw shooters. Previous research has shown that teams with better free-throw skills, especially late in the game, are more likely to win. Although the current study did not include the effects of fatigue on shooting mechanics and accuracy, researchers hope to investigate that factor in upcoming studies, as well as the effect of the presence of a defender on shooting mechanics and accuracy.

    The laboratory is part of the Wu Tsai Human Performance Alliance, a consortium of researchers investigating optimal human performance. This alliance includes Stanford University, University of Oregon, Boston Children’s Hospital, Salk Institute, University of California San Diego and KU.

    “These findings add to the work we have done in the past and to the body of scientific literature related to basketball shooting performance that we are continually expanding in our laboratory,” said Dimitrije Cabarkapa. “We have found that both the preparation and release phases of the shooting motion are critical to achieving solid levels of shooting efficiency. The implementation of innovative technology can allow us to understand the transition phase of the shooting motion and the kinematic chain in more detail Ultimately, our goal is to have an answer to the question every basketball fan wants to know: ‘Why did Steph Curry miss that shot?’”

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  • Exactech announces approval for its new 3D printed Vantage® ankle-tibial implants

    Exactech announces approval for its new 3D printed Vantage® ankle-tibial implants

    GAINESVILLE, Fla., October 26, 2023–(BUSINESS WIRE)–Exactech, a developer and manufacturer of innovative implants, instrumentation and smart technologies for joint replacement surgery, today announced the 510(k) clearance of its new 3D printed tibial implants, the Vantage® Only 3D and 3D+. This is the second recent approval for the broader Vantage Total Ankle System, following Activit-E™, a new advanced vitamin E polyethylene, which received approval from the Food and Drug Administration last month.

    The new implants provide orthopedic surgeons with additional tibial height options for total ankle replacement patients. Both implants are 3D printed and designed with a porous surface that mimics subchondral bone to aid in biological fixation. They are fitted with pointed pegs and a central bone cage, of varying lengths, to achieve initial fixation. The Vantage Ankle 3D builds on the design philosophy of the system’s current tibial offering and is available in a 10mm height. The Vantage Ankle 3D+ is a stem implant with options of 15, 20, 25 and 30 mm.

    “As an original member of the Vantage Ankle design team, I am excited about the next generation, state-of-the-art Vantage Ankle 3D and 3D+ tibial components,” said Mark Easley, MD, of Duke Health. “Developed through the collaborative efforts of our extensive team of expert consultant surgeons and experienced engineers, the redesigned tibial implants feature innovative, intuitive surgical technique and surgeon-friendly instrumentation.”

    The Vantage Ankle 3D and 3D+ are compatible with Exactech’s patient-specific instruments, the Vantage Ankle PSI cutting guides. 3D Systems (NYSE:DDD), manufacturer of the Vantage Ankle PSI, previously received 510(k) clearance for four additional cutting guides, two of which are specifically made for use with these new tibial implants.

    “We are laser-focused on delivering innovative solutions that our surgeons and patients need,” said Devan Carter, Exactech’s foot and ankle marketing director. “With these new additions, the Vantage Ankle now offers solutions from pre-operative planning to complex deformities, bringing us one step closer to providing a complete continuum of care.”

    Full market availability for the Vantage Ankle 3D and 3D+ is expected before the end of 2024. For more information, please contact your local Exactech representative.

    About Exactech

    Exactech is a global medical device company that develops and markets orthopedic implant devices, related surgical instruments and Active Intelligence® platform of smart technologies for hospitals and doctors. Headquartered in Gainesville, Florida, Exactech markets its products in the United States, in addition to more than 30 markets in Europe, Latin America, Asia and the Pacific. Visit www.exac.com for more information and connect with us on LinkedIn, VuMedi, YouTube, Tweet and Instagram. With Exactech by your side you have EXACTLY what you need.

    Contacts

    Samantha DiVirgilio
    Senior Manager Marketing Communications
    media@exac.com



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  • Novel nanoparticle-based system developed for the comprehensive treatment of rheumatoid arthritis

    Novel nanoparticle-based system developed for the comprehensive treatment of rheumatoid arthritis

    shutterstock 390538711 6b3c40fdd32742caa54307db3553cab1

    A team of scientists led by KOO Sagang of Seoul National University and the Center for Nanoparticle Research within the Institue for Basic Science Center (IBS), in collaboration with researchers from the Korea Institute of Science and Technology (KIST) and the Seoul National University, developed a new solution for the treatment of rheumatoid arthritis (RA).

    RA is a chronic disease that unfortunately cannot be cured. The disease causes a mix of troublesome symptoms, such as inflamed joints, harmful cytokines, and immune system imbalances, which work together to create a relentless cycle of worsening symptoms. While addressing some of these factors can provide short-term relief, others remain unresolved, leading to a frustrating cycle of remission and flare-ups.

    One of the biggest hurdles in treating RA is the inability to restore the immune system to a healthy state. This leaves the body unable to control the continued production of harmful substances such as reactive oxygen species (ROS) and inflammatory cytokines, leading to persistent inflammation and discomfort.

    Essentially, the ideal treatment for RA should not only provide immediate relief from inflammation and symptoms, but also address the cause by restoring the immune system to its normal, balanced state.

    New nanoparticle-based system as a solution

    The novel platform involves immobilizing ceria nanoparticles (Ce NPs) on mesenchymal stem cell-derived nanovesicles (MSCNVs). Both components can hinder various pathogenic factors, allowing them to work individually and together to achieve comprehensive treatment.

    Ce NPs – can scavenge the overproduction of ROS in RA-induced knee joints. They also cause polarization of M1 macrophages into M2, immediately relieving inflammation and symptoms.

    MSCNVs – deliver immunomodulatory cytokines, which convert dendritic cells (DC) into tolerogenic dendritic cells (tDCs). This consequently generates regulatory T cells for long-term immune tolerance.

    In short, this approach aims to bridge both innate and adaptive immunity to achieve short-term pain relief, and to convert the tissue environment into an immune-tolerant state to prevent recurrence of symptoms.

    Researchers confirmed the efficacy of this approach using a collagen-induced arthritis mouse model. The Ce-MSCNV system was able to comprehensively treat and prevent RA by simultaneously easing and restoring immediate T cell immunity. Supporting data suggests that improvement in conditions can be achieved after only a single dose treatment.

    The mice treated with the Ce-MSCNV combination did much better compared to the mice treated with the Ce NP or MSCNV group alone. This clearly demonstrates the synergy between anti-inflammatory agents and immunomodulation and underlines the importance of the combined therapy for effective treatment of RA. Furthermore, administration of Ce-MSCNV prior to booster injection significantly reduced the incidence and severity of symptoms, supporting the prophylactic potential of these nanoparticles.

    One of the most difficult decisions in the treatment of intractable diseases is determining how long to continue treatment. For RA, it would not be appropriate to stop treatment just because the target marker has stabilized. A safer indicator should be that the innate and adaptive components of the collapsed immune system are normalized to protect the body.”


    Koo Sagang, first author

    Koo believes that Ce-MSCNVs’ strategy of working together with different treatment mechanisms offers a unique advantage in this regard. Furthermore, she predicts that a similar approach for this purpose would also be applicable to other refractory, inflammatory and autoimmune diseases. The components within the system can also be changed. For example, depending on the type of disease, other catalysts can be used to generate ROS or other cell-derived nanovesicles. Overall, this study proves the potential of a hybrid nanoparticle system for the comprehensive treatment of autoimmune diseases and modulation of the immune system.

    Source:

    Institute for Basic Sciences

    Magazine reference:

    Koo, S., et al. (2023). Ceria-vesicle nanohybrid therapeutic agent for modulation of innate and adaptive immunity in a collagen-induced arthritis model. Nature Nanotechnology. doi.org/10.1038/s41565-023-01523-y.

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  • Put down the drink;  Alcohol use after a concussion can prolong symptoms in collegiate athletes

    Put down the drink; Alcohol use after a concussion can prolong symptoms in collegiate athletes

    Alcohol use after injury is associated with prolonged recovery from concussion in NCAA athletes

    Chang RC, Singleton M, Chrisman SPD, et al. Alcohol use after injury is associated with prolonged recovery from concussion in NCAA athletes. Clin J Sport Med. Published online 2023:1-8. doi:10.1097/JSM.0000000000001165

    https://journals.lww.com/cjsportsmed/Abstract/9900/Postinjury_Alcohol_Use_Is_Associated_With.142.aspx

    Take home message

    Collegiate athletes can experience long-lasting concussion symptoms if they consume alcohol during recovery. The severity of symptoms may not differ among those who consume alcohol during recovery.

    Background

    Concussions lead to immediate and variable symptoms that affect quality of life. Many collegiate athletes consume alcohol regularly, but there is no consensus regarding the effects of alcohol consumption after a concussion on symptoms.

    Study aim

    The authors used a prospective cohort to assess whether alcohol consumption after concussion is associated with resolution of concussion symptoms. The authors also evaluated the impact of alcohol consumption on symptom severity.

    Methods

    The authors used data from the ongoing Concussion Assessment Research and Education (CARE) Consortium. The authors analyzed data from 29 different clinical sites and 484 of 3,518 athletes with concussion. An athlete who reported consuming at least one alcoholic beverage per week during concussion recovery was considered an alcohol user. The authors used the Sport Concussion Assessment Tool 3 (SCAT3) symptom score sheet to track outcomes after concussion.

    Results

    Athletes who drank alcohol after a concussion took an average of 22 days to return to full participation in sports. This represents a 33% delay in return to play compared to those who did not consume alcohol after injury. On average, those who drank alcohol after a concussion needed about five additional days to return to full-time sports. Additionally, the more alcohol consumed after the concussion, the longer it took for symptoms to resolve. Alcohol consumption had no influence on the severity of symptoms.

    Viewpoints

    This study clarifies previous research on the relationship between post-concussion alcohol use and delayed symptom resolution. The delay in symptom resolution may contribute to deconditioning among those who have consumed alcohol after a concussion, which could hinder their willingness to contribute to team success. Interestingly, alcohol consumption after an injury does not play a role in the severity of symptoms, according to this study. This suggests that alcohol may slow the healing process rather than causing additional tissue damage. While these results are important, this study did not standardize a “drink.” Therefore, there is a possibility that different types and volumes of alcohol consumed per drink could influence symptom resolution. Furthermore, the authors focused on less than 15% of athletes with a concussion. Therefore, it will be important to replicate these findings to see if they apply to the broader athletic concussion population.

    Clinical implications

    In practice, physicians should encourage athletes diagnosed with a concussion to reduce alcohol intake or, ideally, to abstain from alcohol consumption until symptoms resolve. Clinicians should also educate athletes about the role alcohol consumption after injury plays in prolonging concussion symptoms.

    Questions for discussion

    What strategies, if any, do you use to educate athletes about alcohol consumption after a concussion? What changes do you plan to make to patient education based on this research?

    related posts

    1. Gender-specific predictors of long-term recovery from concussion
    2. Suggested answer to the most common question about concussions: How many days until I can play?
    3. Concussion: Is Submaximal Exercise Medicine?

    Written by Cade Watts
    Reviewed by Jeffrey Driban

    Evidence-based assessment of concussion course - 5 EBP CEUs

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  • Osteoporosis under a microscope and functional culinary medicine with Dr.  Monisha Bhanote, MD + BoneCoach™ – BoneCoach™

    Osteoporosis under a microscope and functional culinary medicine with Dr. Monisha Bhanote, MD + BoneCoach™ – BoneCoach™

    your bones under the microscope?

    Curious about how preventive measures can be taken change the course of osteoporosis?

    Interested in learning about functional culinary medicine and whether it can be useful in supporting strong bones?

    Then this episode is for you!

    I was on board Dr. Monisha Bhanote, a five-time board-certified physician and best-selling author. We delved deep into it together the microscopic world of bonesrevealing the causes, preventive measures and the most important nutritional value secrets that everyone with osteoporosis should know.

    Episode timeline

    0:00 – Episode begins

    1:18 – Introduction to Dr. Monisha Bhanote

    3:14 – Dr.’s professional background Bhanote

    5:29 – Discuss the importance of biopsies

    9:39 – Delving into bone cells and their components under the microscope

    10:19 – Osteoblasts, osteoclasts and osteocytes

    13:23 – Discussion about bone diseases, especially osteoporosis and osteopenia

    16:16 – Defining degenerative joint disease

    18:43 – Other important conditions observed under the microscope

    23:36 – Preventive measures and diagnostic tests to avoid osteoporosis and other extreme health situations

    25:40 – Essential nutrients for osteoporosis prevention and better bone health

    30:30 – Overview of mechanisms at the cellular level, including RANKL

    36:34 – A look at functional culinary medicine

    42:52 – How Dr. Bhanote helps her patients and where to find her

    Sources mentioned

    **Show notes @ https://bonecoach.com/drmonishabhanote-functional-culinary-medicine

    Below you will find resources from Dr. Monisha Bhanote!

    >> Connect with Dr. Bhanote here on her website

    >> View Dr.’s book here. Bhanote, The Anatomy of Wellbeing

    What can you do to support your bone health and this podcast?

    1. Press the “Subscribe” button on your respective podcast player (i.e. Apple, Google, Spotify, Stitcher, iHeart Radio and TuneIn). Never miss an episode that can help improve your bone health.

    2. Leave a review. The more positive ratings and reviews and the more subscribers we have, the more people can find us and get the answers to the questions they need. Thank you! 🙂

    3. Tell a friend about The Bone Coach Podcast or share via text, email or social. Do you know of a Facebook group where people can benefit from this information? Feel free to click any of the share buttons below.

    About Dr. Monisha Bhanote, MD:

    Dr. Monisha Bhanote, the founder Wellkulå, is a quintuple board-certified physician and best-selling author with expertise in integrative medicine, functional culinary medicine, cytopathology, and anatomic/clinical pathology.

    After graduating from Binghamton University with a double degree in chemistry and Asian studies, she received her medical degree and completed a residency at NYU Winthrop University Hospital. This was followed by three fellowships in Cytopathology at Cornell, Breast, Bone & Soft tissue Cancer at the University of Rochester, and Integrative Medicine at the Andrew Weil Center for Integrative Medicine Arizona.

    Dr. Bhanote has additional training and certifications in mindfulness-based stress reduction, plant-based nutrition, culinary medicine, Ayurveda, yoga for cancer recovery, and a therapeutic specialist in yoga medicine. She applies a whole body approach to healing.

    She is a sought-after health and wellness expert who provides both spoken and written commentary for multiple news media and publications. Her interests include nutrition and the microbiome, the role of stress and inflammation in disease manifestation, practicing mindfulness as a lifestyle, and disease prevention. Dr.’s mission Bhanote is supporting an integrative approach to evidence-based holistic wellness.

    Medical disclaimer

    The information shared above is for informational purposes only and is not intended as medical or nutritional therapy advice; it does not diagnose, treat or cure any disease or condition; it should not be used as a substitute or substitute for medical advice from physicians and trained medical professionals. If you are under the care of a healthcare professional or are currently taking prescription medications, you should discuss any changes in your diet and lifestyle or possible use of nutritional supplements with your doctor. You should not stop prescribed medications without first consulting your doctor.

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  • Warning!  Scientists are repeating old mistakes in their attempt to create a new osteoporosis drug

    Warning! Scientists are repeating old mistakes in their attempt to create a new osteoporosis drug

    A recent study has revealed a new osteoporosis drug in development. However, the direction the researchers are taking is very similar to an existing drug against osteoporosis: Evenity (romosozumab).

    The researchers promote their methodology as a revolutionary approach to drug development, even though the synthetic molecule they created closely resembles an existing osteoporosis drug.

    We will look at this new drug in development and how it compares to other medications and their side effects.

    Bio-inspired molecules built to target bone

    Researchers from several biotechnology and medical institutions have collaborated to develop new ‘bio-inspired’ molecules that improve bone regeneration in mice.

    Their research, published in the journal Biomaterials, highlights their use of computer modeling and testing to more effectively bioengineer molecules inspired by biology. They designed the synthetic compounds to interact with natural pathways related to bone remodeling.1

    The molecules, called Rationally Engineered Oligomeric Glycosaminoglycan Derivatives (reGAG), are designed to block the signaling pathways of two naturally occurring proteins: Dickkopf-1 (DKK1) and sclerostin. Both proteins inhibit the development of osteoblasts, the cells responsible for generating new bone.1

    The researchers believe that these new molecules could be used to develop new drugs that help the body regenerate bones more efficiently. Their eyes are clearly on the osteoporosis drug market. However, despite their unique development method, they have not yet discovered a new route for artificially accelerated bone growth.

    Short content

    Biotech and medical researchers have joined forces to design a new synthetic molecule that inhibits two proteins: DKK1 and sclerostin. These proteins inhibit the formation of the cells that build new bone, osteoblasts. Although the process for making these molecules is new, this mechanism of action has already been tried by other drugs.

    Romosozumab Redux

    The new molecule, reGAG, targets the protein sclerostin, which has had a controversial history in the medical industry. Sclerostin is the target of a well-known osteoporosis drug: Evenity, also known as romosozumab.

    Evenity is an injectable osteoporosis drug that inhibits sclerostin. This action results in more osteoblast formation, which leads to increased production of new bone. However, the drug stops working over time and patients must then be switched to a bisphosphonate to try to maintain the increase in bone mineral density.

    This temporary increase in bone mineral density comes at no cost. Romosozumab was originally rejected by the FDA due to the risk of heart attack. It was too dangerous to prescribe.

    However, the following year, Amgen, the pharmaceutical giant behind Evenity, resubmitted the identical drug. The FDA has approved it only for women considered to be at highest risk for fractures. Of course, the drug still carries significant risks.

    Additional studies have confirmed the heart health risks of romosozumab and directly linked it to sclerostin inhibition.2 That’s the same mechanism of action claimed in the new study, along with the inhibition of another protein called Dickkopf-1 (DKK1).

    Short content

    The new molecule reGAG inhibits sclerostin to increase bone formation. That’s the same mechanism of action as romosozumab (Eventiy), an osteoporosis drug that increases the risk of heart attack and other cardiovascular diseases.

    DKK1: More of the same

    The other protein inhibited by this newly manufactured bioinspired molecule is Dickkopf-1 (DKK1).

    Studies have shown that this protein is critical for the development of the embryonic heart, head and forelimbs. It is also critical for bone development and bone health in adults.3

    Like sclerostin, DKK1 is known to inhibit bone repair by suppressing osteoblast formation. That’s why researchers are focusing on it in addition to sclerostin. However, it remains to be seen what unintended consequences will result from inhibiting this naturally occurring protein.

    If the “bioinspired” compounds that inhibit DKK1 and sclerostin are developed into a drug, the inclusion of DKK1 inhibition could introduce new side effects to an already risky osteoporosis treatment.

    ‌‌Short content

    DKKI is a protein essential for embryonic development. Later, it helps regulate bone formation by inhibiting osteoblast formation, just like sclerostin. However, unlike sclerostin, we do not yet know the possible side effects of a drug that artificially disables this naturally occurring protein.

    What this means for you

    Although Big Pharma is constantly searching for new drugs, the results often show limited effectiveness and harmful side effects. This further highlights the importance of an integrative and natural approach to bone health.

    The Osteoporosis Reversal Program offers a holistic, drug-free program with positive changes that will result in stronger bones and better health. It takes more effort than a pill and more time than an injection, but the results are well worth it.

    Embrace a life of freedom, confidence, and independence by staying committed to your all-natural bone health regimen!

    References

    1 https://www.sciencedirect.com/science/article/abs/pii/S0142961223001138?via%3Dihub

    2 https://stm.sciencemag.org/content/12/549/eaay6570

    3 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2628360/



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  • Nutrition for better performance

    Nutrition for better performance

    Through jeff bloom AT, CSCS Ahwatukee FAST

    I often get asked by athletes, “What should I eat?” That’s a pretty vague question, and there really isn’t just one answer. However, there are some simple nutritional guidelines that can help an athlete achieve better performance. In general, athletes should eat a diet that is high in carbohydrates, low in saturated fats, and contains enough protein to rebuild the muscle breakdown that occurs during their training.

    A wooden bowl of protein-rich oats.

    Carbohydrates for energy

    Carbohydrates are our main source of energy and the fuel we need to compete at a high level. a diet that contains 60% of total calories from carbohydrates is recommended for most athletes. These carbohydrates should come from whole wheat pasta/bread, rice, potatoes, fruit and starchy vegetables.

    Protein for better performance

    All athletes know that egg white is an important nutrient for better performance, but many protein sources also contain saturated fats that should be avoided. Quality protein choices include lmeat, fish, low-fat dairy products, poultry and beans. Protein intake depends on the size of the athlete, the activity the athlete is doing and the athlete’s overall goals. A good rule of thumb is 0.5 – 0.75 g protein/kg body weight. Athletes looking to increase their muscle mass or those who experience extreme muscle wasting during their sport may require higher levels.

    011118 healthy food thinkstock600 854725402

    Good fats or bad fats?

    Fats have a bad reputation, but are also an important part of any diet. Athletes have to make ends meet 20% of their calories from fat. The key is being able to distinguish the ‘good’ fats from the ‘bad’ fats. “Good” or unsaturated fat can be found in nuts, oils and fish.

    Finding a good diet plan is a very individual process and depends on a number of variables. Following the steps above will help you build a solid nutritional foundation and get most athletes moving in the right direction. From there, with just a little adjustment, you can compete at a higher level than ever before!

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