download 2026 03 25T200618.431
|

Breakthrough for ‘neglected’ rheumatic disease

Scientists have had success treating a ‘neglected’ inflammatory disease, polymyalgia rheumatica, with a drug that could offer patients an alternative to steroids.

The study, conducted by Anglia Ruskin University (ARU) and published in the New England Journal of Medicine, describes a successful trial of sarilumab. The drug, approved in Britain to treat rheumatoid arthritis, blocked the protein interleukin-6, which can cause inflammation.

Polymyalgia rheumatica (PMR) is characterized by pain and morning stiffness in the shoulder and hips and affects people over the age of 50. It can significantly affect quality of life and is currently mainly treated with the steroid glucocorticoids.

Although glucocorticoids can control the condition, more than half of PMR patients experience a relapse of their condition when they reduce their steroid medication. Interleukin-6 has been implicated in the pathophysiology of PMR because circulating elevated levels and increased tissue expression of interleukin-6 have been found in PMR patients.

During the year-long clinical trial conducted by researchers, 118 patients received either twice-monthly injections of sarilumab or a placebo. The sarilumab group received a tapering dose of glucocorticoid for 14 weeks in combination with bimonthly injections of sarilumab, while the placebo group received a tapering dose of glucocorticoid for 52 weeks.

The primary outcome at the end of the study was sustained remission of the condition. This happened in 28% of people taking sarilumab, compared to 10% of people taking the placebo. After achieving remission at 12 weeks, there were more disease flares in the placebo group (57%) compared to those who received sarilumab (24%).

Lead PMR expert and senior author of the study, Professor Bhaskar Dasgupta, from Anglia Ruskin University’s Medical Technology Research Center (ARU), said: “Polymyalgia rheumatica is a poorly managed and neglected condition for which current treatment is unsatisfactory and long time can take. Long-term side effects: Patients may experience relapses while tapering their medications, and very limited treatment options currently exist for these relapses.

“Our findings show promise that sarilumab can be used to treat PMR and improve outcomes for people coming off steroid medications.

“This is an exciting development that has the potential to improve treatment options for a condition common in older people. PMR is the most common reason for long-term steroid prescriptions. Any effective drug that can spare the use of steroids would be a should have a major impact.” on reducing the serious side effects of such steroids, including diabetes, osteoporotic fractures and infections.”

The research was funded by Sanofi and Regeneron Pharmaceuticals.

Source link

Similar Posts

  • |

    Knee replacement complications

    What if the key to a successful recovery isn’t just about the surgery itself, but what you know beforehand? Every year, over 790,000 people in the United States choose this medical procedure to regain their mobility. It’s a major step toward a life with less pain. knee replacement complications We recognize that while this operation is common, understanding what can happen after is vital. This knowledge transforms a patient from a passive recipient into an active partner in their own care. Our goal is to provide clear, empowering information about the possible risks. This helps you approach your healing journey with eyes wide open and confidence high. Modern advancements have made this intervention safer and more effective than ever. Still, being informed allows you to spot any warning signs early and seek help promptly. This guide is your comprehensive resource. We aim to support you in taking charge of your long-term joint health and overall well-being. Key Takeaways Over three-quarters of a million knee replacement surgeries are performed annually in the U.S. Being informed about potential issues is a crucial part of patient preparation and empowerment. Knowledge of risks helps in early identification of any post-operative warning signs. Modern surgical techniques and care have significantly improved the safety profile of this procedure. An active understanding of your care plan contributes greatly to a successful long-term outcome. This information is designed to build confidence as you move forward with your medical decision. Understanding Knee Replacement Surgery Before diving into the details, let’s build a clear picture of what this surgical process entails. Over 790,000 of these operations happen each year in the United States alone. understanding knee replacement surgery What Is a Knee Replacement? This common operation replaces all three compartments of a damaged joint. Surgeons remove worn bone and cartilage. They then fit precise metal and plastic implants. This creates a new, smooth gliding surface. Aspect Detail Primary Goal Relieve chronic pain and restore joint function Artificial Components Metal and medical-grade plastic Typical Anesthesia General or spinal Average Hospital Stay 1 to 3 days Initial Recovery Period 6 to 12 weeks The Overall Procedure and Its Benefits This intervention is designed to help people regain independence. Most patients report a major improvement in their quality of life. The main benefit is lasting relief from persistent pain. Many return to daily activities and hobbies they love. Understanding the mechanics helps set realistic expectations for recovery and long-term performance. Key Knee Replacement Complications Statistics offer great comfort, but a complete picture includes understanding what could go wrong, even if it’s unlikely. Research confirms a very high success rate for this operation. Over 95% of people recover without any major issues. This statistic highlights the overall safety of the procedure. key knee replacement complications Overview of Common Risks Every medical intervention carries some inherent risks. These can include infection, blood clots, or stiffness. Your surgical team is trained to both prevent and manage these known challenges. They are a standard part of the pre-operative discussion. Why Awareness Matters We believe knowledge is power. Understanding potential warning signs allows you to partner with your care team. You can seek help promptly if something doesn’t feel right. This proactive approach helps prevent minor concerns from becoming serious problems. It’s crucial to discuss your personal health history with your doctor. This conversation helps assess your individual risk profile before surgery….

  • Understanding Knee Osteoarthritis & Whole Body Impact

    Welcome to our comprehensive guide on knee osteoarthritis and its impact on the whole body. Knee osteoarthritis (OA) is a common condition, primarily affecting the elderly, and it can have a significant effect on joint health and overall well-being. In this article, we will explore the causes, symptoms, diagnosis, and treatment options for knee OA,…

  • |

    4 women get real about living with rheumatoid arthritis

      Your immune system is supposed to protect your body, but when you have rheumatoid arthritis (RA), it accidentally attacks healthy joints, tissues, and organs, including the eyes and lungs. As a result, the chronic autoimmune disease causes pain, swelling, stiffness and loss of function in the joints. It can also cause other symptoms, including…

  • Piriformis Syndrome Is a Pain in the Butt: Understand the Causes, Symptoms, and Stretches to Get Rid of It Fast – ACL Strong

    Piriformis syndrome is a common but often misunderstood condition that causes pain, numbness, and tingling in the buttocks and legs. This syndrome occurs when the piriformis muscle, located deep in the buttocks, compresses or irritates the sciatic nerve. Understanding the anatomy, causes, aggravating activities, and effective stretches is crucial to effectively treating this condition. Anatomy:…

  • Exploring Ayurveda: The Natural Law of Health with Amish Shah + BoneCoach™ – BoneCoach™

      Tired of unanswered questions about your healtheven after countless doctor visits? Interested in the age-old wisdom of Ayurveda and its role in modern healthcare? Would it be possible that the missing link in your osteoporosis journey has been around for thousands of years? If you’re looking for answers, this episode is a must see!…

Leave a Reply

Your email address will not be published. Required fields are marked *